GDC 0941, pan-PI3K kinase inhibitor

• Catalog number
  SIH-501-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  957054-30-7
• Description
  pan-PI3K kinase inhibitor
• Molecular weight
  513,63 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  Pictrelisib, Pictilisib, GNE 0941, 2-​(1H-​indazol-​4-​yl)-​6-​[[4-​(methylsulfonyl)-​1-​piperazinyl]methyl]-​4-​(4-​morpholinyl)-​thieno[3,​2-​d]pyrimidine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C23H27N7O3S2
• Origin
  Synthetic
• Purity pourcentage
  ≥98%
• Soluble in
  Soluble in DMSO
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  17755052
• Scientific context
  GDC 0941 is a potent inhibitor of the PI 3-kinase family. Specifically, GDC 0941 has been shown to inhibit PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ.
• Bibliography
  1. Zheng J., Wang H., Yao J., & Zou X. (2014) Die Pharmazie. 69(1): 38–42.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of GDC 0941 (SIH-501), a pan-PI3K kinase inhibitor. CAS #: 957054-30-7. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.63 g/mol. Chemical structure of GDC 0941, a pan-PI3K kinase inhibitor (SIH-501). CAS # 957054-30-7. Molecular Formula: C23H27N7O3S2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  GDC   0941   pan-PI3K   kinase   inhibitor  
• Gene symbol
  PIK3C2B, PIK3CA, PIK3C2A, PIK3R5
• Short name
  GDC 0941, pan-PI3K kinase inhibitor
• Alternative name
  GDC 0941, pan-PI3K phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:8972
• Gene
  PIK3C2B
• Long gene name
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
• Synonyms gene name
  • phosphoinositide-3-kinase, class 2, beta polypeptide
  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
• Synonyms
  • C2-PI3K
  • PI3K-C2beta
• GenBank acession
  • Y11312
• Locus
  1q32.1
• Discovery year
  1998-05-21
• Entrez gene record
  5287
• Pubmed identfication
  • 9144573
  • 9830063
• RefSeq identity
  • NM_002646
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000036101

Gene info

• Identity
  HGNC:8975
• Gene
  PIK3CA
• Long gene name
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
• Synonyms gene name
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
• Synonyms
  • PI3K
• Locus
  3q26.32
• Discovery year
  1994-07-15
• Entrez gene record
  5290
• Pubmed identfication
  • 1322797
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000157311
• Locus Specific Databases
  • LRG_310

Gene info

• Identity
  HGNC:8971
• Gene
  PIK3C2A
• Long gene name
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
• Synonyms gene name
  • phosphoinositide-3-kinase, class 2, alpha polypeptide
  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
• Synonyms
  • PI3K-C2alpha
• GenBank acession
  • Y13367
• Locus
  11p15.1
• Discovery year
  1998-05-21
• Entrez gene record
  5286
• Pubmed identfication
  • 9337861
• RefSeq identity
  • NM_002645
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000166036

Gene info

• Identity
  HGNC:30035
• Gene
  PIK3R5
• Long gene name
  phosphoinositide-3-kinase regulatory subunit 5
• Synonyms gene name
  • phosphoinositide-3-kinase, regulatory subunit 5
• Synonyms
  • P101-PI3K
  • p101
• GenBank acession
  • AF128881
• Locus
  17p13.1
• Discovery year
  2004-10-13
• Entrez gene record
  23533
• Pubmed identfication
  • 12507995
• RefSeq identity
  • NM_014308
• VEGA ID
  OTTHUMG00000108197

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