GDC-0449

• Catalog number
  1890-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
• Description
  A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
• CAS Number
  879085-55-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₁₄Cl₂N₂O₃S
• Molecular Weight
  421.3
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
• Handling
  Protect from air and light
• Tag Line
  A Smoothened (Smo) antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD12407408
• PubChem CID
  24776445
• PubChem CID Link
• SMILES
  CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
• InChi
  InChI=1S/C19H14Cl2N2O3S/c1-27(25, 26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22- 18/h2-11H,1H3,(H,23,24)
• InChi Key
  BPQMGSKTAYIVFO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GDC-0449  
• Short name
  GDC-0449
• Alternative name
  GDC-0449

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