PSI-7977

Alternative_name

(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; Sofosbuvir; brand name: Sovaldi and Virunon.
Description

PSI-7977 is a phosphoramidate nucleotide prodrug for the treatment of hepatitis virus. It acts as a selective inhibitor of hepatitis C virus (HCV) NS5B polymerase.
CAS Number

1190307-88-0
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₂H₂₉FN₃O₉P
Molecular Weight

529.45
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~ 20 mg/ml) or EtOH (~ 20 mg/ml)
Handling

Protect from air and light
Tag Line

Aselective inhibitor of hepatitis C virus (HCV) NS5B polymerase.
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

36 months
PubChem CID

45375808
PubChem CID Link
SMILES

CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
InChi

InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
InChi Key

TTZHDVOVKQGIBA-IQWMDFIBSA-N
Data Sheet Link
MSDS Available

Yes