GDC-0980

• Catalog number
  2668-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
• Description
  GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR with Ki of 17 nM. GDC-0980 is highly selective versus others PIKK family kinases. Displays anticancer activity.
• CAS Number
  1032754-93-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₃₀N₈O₃S
• Molecular Weight
  498.6
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent PI3K/mTOR kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  25254071
• PubChem CID Link
• SMILES
  CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O
• InChi
  InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
• InChi Key
  YOVVNQKCSKSHKT-HNNXBMFYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GDC-0980  
• Short name
  GDC-0980
• Alternative name
  GDC-0980

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