DUB Inhibitor, NSC-632839

• Catalog number
  2570-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
• Description
  Cell-permeable. A pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.
• CAS Number
  157654-67-6
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₁NO · HCl
• Molecular Weight
  339.86
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~8 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A pan-specific ubiquitin isopeptidase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• PubChem CID
  5351362
• PubChem CID Link
• SMILES
  CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl
• InChi
  InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;
• InChi Key
  ZOKZLTXPTLIWOJ-BYCVLTJGSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  DUB   Inhibitor   NSC-632839  
• Short name
  DUB Inhibitor, NSC-632839
• Alternative name
  DUB suppressor, NSC-632839

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