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Stock availabilitIn Stock
In Stock
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CAS number
668467-91-2
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Description
DUB inhibitor
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Molecular weight
397,6 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C17H11Cl3N2O3
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in 20 mg/ml DMSO
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Physical appearance
Yellow Powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves.
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PubChem number
16760696
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Scientific context
Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
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Bibliography
1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.
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Release date
6-Jun-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of LDN-57444 (SIH-332), a DUB inhibitor. CAS #: 668467-91-2. Molecular Formula: C17H11Cl3N2O3. Molecular Weight: 397.6 g/mol. Chemical structure of LDN-57444, a DUB inhibitor (SIH-332). CAS # 668467-91-2. Molecular Formula: C17H11Cl3N2O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
