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Stock availabilitIn Stock
In Stock
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CAS number
30675-13-9
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Description
DUB inhibitor
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Molecular weight
283,9 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C9H2Cl4O2
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Origin
Synthetic
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Purity pourcentage
>97%
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Soluble in
Soluble in 25 mg/ml DMSO
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Precautionary Statements: P260- Do not breathe dust/fume/gas/mist/vapours/spray. P285- In case of inadequate ventilation wear respiratory protection. P305+P351+P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310- Immediately call a POISON CENTER or doctor/physician. P501- Dispose of contents/container in accordance with international regulations. Hazard Statements: H334- May cause allergy or asthma symptoms or breathing difficulties if inhaled H373- May cause damage to organs through prolonged or repeated exposure H318- Causes serious eye damage H410- Very toxic to aquatic life with long lasting effects H317- May cause an allergic skin reaction
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PubChem number
2729042
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Scientific context
Inhibits ubiquitin C-terminal hydrolase L3 (UCH UCHL3). IC50=0.6 M, 125-fold selective over UCHL1, IC50=75 M. Cell permeable.
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Bibliography
1. Love K.R., et al. (2007) Nat. Chem. Biol. 3: 697. 2. Mtango N.R. et al. (2012) J. Cell Physiol. 227: 2022.
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Release date
6-Jun-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of TCID (SIH-340), a DUB inhibitor. CAS #: 30675-13-9. Molecular Formula: C9H2Cl4O2. Molecular Weight: 283.9 g/mol. Chemical structure of TCID, a DUB inhibitor (SIH-340). CAS # 30675-13-9. Molecular Formula: C9H2Cl4O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
