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Stock availabilitIn Stock
In Stock
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CAS number
856243-80-6
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Description
DUB inhibitor
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Molecular weight
384,3 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C19H18BrN3O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol
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Physical appearance
Pale Yellow Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
11222830
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Scientific context
A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination.
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Bibliography
1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.
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Release date
6-Jun-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of WP-1130 (SIH-337), a DUB inhibitor. CAS #: 856243-80-6. Molecular Formula: C19H18BrN3O. Molecular Weight: 384.3 g/mol. Chemical structure of WP-1130, a DUB inhibitor (SIH-337). CAS # 856243-80-6. Molecular Formula: C19H18BrN3O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
