Bml 277 ,CHK2 kinase inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

516480-79-8
MolecularFormula

C20H14ClN3O2
Molecular Weight

363.8
Purity

≥98% (TLC)
Solubility

Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml)
Appearance

Off-white solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Identity

HGNC:16627
Gene

CHEK2
Long gene name

checkpoint kinase 2
Synonyms gene
- RAD53
Synonyms gene name
- CHK2 (checkpoint, S.pombe) homolog
- CHK2 checkpoint homolog (S. pombe)
Synonyms
- CDS1
- CHK2
- HuCds1
- PP1425
- bA444G7
GenBank acession
- AF086904
Locus

22q12.1
Discovery year

2001-09-19
Entrez gene record

11200
Pubmed identfication
- 9836640
- 10097108
RefSeq identity
- NM_001005735
VEGA ID

OTTHUMG00000151023
Locus Specific Databases
- LRG_302