Bml 259, CDK5, p25 kinase inhibitor
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Catalog numberSIH-435-25MG
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PricePlease ask
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Size25 mg
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Stock availabilitIn StockIn Stock
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CAS number267654-00-2
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DescriptionCDK5, p25 kinase inhibitor
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Molecular weight260,4 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other nameN-(5-Isopropylthiazol-2-yl)phenylacetamide
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC14H16N2OS
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OriginSynthetic
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Purity pourcentage≥98% (TLC)
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Soluble inSoluble in DMSO (30 mg/ml), dimethyl formamide (30 mg/ml) or 100% ethanol (0.25 mg/ml)
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number16760027
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Scientific contextBml 259 is a potent inhibitor of Cdk5/p25. It also inhibits Cdk2/cyclin E.
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Bibliography1. Kaźmierczak A., Czapski G.A., Adamczyk A., Gajkowska B., & Strosznajder J.B. (2011) Neurochem. Int. 58(2): 206–214.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of BML 259 (SIH-435), a CDK5/p25 kinase inhibitor. CAS #: 267654-00-2. Molecular Formula: C14H16N2OS. Molecular Weight: 260.4 g/mol. Chemical structure of BML 259, a CDK5/p25 kinase inhibitor (SIH-435). CAS # 267654-00-2. Molecular Formula: C14H16N2OS.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.025
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolCDK5
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Short nameBml 259, CDK5, p25 kinase inhibitor
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Alternative nameBml 259, cyclin-dependent kinase 5, p25 phosphorylation catalyst suppressor
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Alternative to gene targetcyclin-dependent kinase 5, PSSALRE, CDK5 and IDBG-48977 and ENSG00000164885 and 1020, transferase activity, nuclei, Cdk5 and IDBG-141112 and ENSMUSG00000028969 and 12568, CDK5 and IDBG-637527 and ENSBTAG00000007766 and 281066
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Gene info
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Identity
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Gene
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Long gene namecyclin dependent kinase 5
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-07-28
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Entrez gene record
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Pubmed identfication
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Classification
- Cyclin dependent kinases
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VEGA ID