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Stock availabilitIn Stock
In Stock
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CAS number
471-05-6
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Description
NF-κB kinase inhibitor
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Molecular weight
218,3 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H22O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO (≥10 mg/ml)
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Physical appearance
White to off-white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
5470187
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Scientific context
Potentiates TRAIL-induced apoptosis via upregulation of death receptor DR4 and DR5 expression. Has no cytotoxic effect on normal cells. Cell permeable. Natural sesquiterpene ketone isolated from Zingiber sp.
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Bibliography
1. Leu J.L., et al. (2009) Mol Cell. 36:15.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Zerumbone (SIH-265), a Enhances apoptotic effect of TRAIL. CAS #: 471-05-6. Molecular Formula: C15H22O. Molecular Weight: 218.3 g/mol. Chemical structure of Zerumbone, a Enhances apoptotic effect of TRAIL (SIH-265). CAS # 471-05-6. Molecular Formula: C15H22O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
