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Stock availabilitIn Stock
In Stock
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CAS number
78824-30-3
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Description
HAT inhibitor
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Molecular weight
602,8 g/mol
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Primary research fields
Cell Signaling, Epigenetics
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Other name
Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C38H50O6
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Origin
Synthetic
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Purity pourcentage
>98% (TLC), NMR conforms
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Soluble in
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
5490884
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Scientific context
Potent inhibitor of histone acetyl transferases p300 (IC50=7 mM) and pCAF (IC50=5 mM) (1). Induces apoptosis in various cell lines (2). Promotes expansion of human hematopoietic stem cells(3). Cell permeable.
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Bibliography
1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716. 2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456. 3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.
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Release date
17-Sep-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Garcinol (SIH-355), a HAT inhibitor. CAS #: 78824-30-3. Molecular Formula: C38H50O6. Molecular Weight: 602.8 g/mol. Chemical structure of Garcinol, a HAT inhibitor (SIH-355). CAS # 78824-30-3. Molecular Formula: C38H50O6.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
