Garcinol

Alternative_name

Camboginol
Description

Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.
CAS Number

78824-30-3
Structure Available

Yes
Molecular Formula

C₃₈H₅₀O₆
Molecular Weight

602.8
Cell Permeable

Yes
Purity

≥95% by TLC
Solubilities

DMSO (25 mg/ml) or EtOH (25 mg/ml)
Handling

Protect from air and light
Tag Line

A potent histone acetyltransferases (HATs) p300 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD03700761
PubChem CID

3531
PubChem CID Link
SMILES

CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
InChi

InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
InChi Key

DTTONLKLWRTCAB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes