C-646, HAT inhibitor
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Catalog numberSIH-350-25MG
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PricePlease ask
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Size25 mg
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Stock availabilitIn StockIn Stock
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CAS number328968-36-1
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DescriptionHAT inhibitor
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Molecular weight445,4 g/mol
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Primary research fieldsCell Signaling, Epigenetics
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Other name4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC24H19N3O6
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OriginSynthetic
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Purity pourcentage>98% (TLC), NMR conforms
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Soluble inSoluble in 10 mg/ml DMSO
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Physical appearanceOrange Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number1285940
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Scientific contextPotent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
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Bibliography1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471. 2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644. 3. Marek R., et al. (2011) J. Neurosci. 31: 7486. 4. Min S.W., et al. (2010) Neuron 67: 953.
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Release date1-Aug-2012
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of C-646 (SIH-350), a HAT inhibitor. CAS #: 328968-36-1. Molecular Formula: C24H19N3O6. Molecular Weight: 445.4 g/mol. Chemical structure of C-646, a HAT inhibitor (SIH-350). CAS # 328968-36-1. Molecular Formula: C24H19N3O6.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.025
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolTMPRSS11D, SMC4, MIR646, MYB, PCK1, SFTPC, VCX3B, MAF, RFX1, EGR4
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Short nameC-646, HAT inhibitor
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Alternative nameC-646, HAT suppressor
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Gene info
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Identity
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Gene
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Long gene nametransmembrane serine protease 11D
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Synonyms gene name
- transmembrane protease, serine 11D
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-03-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Type II transmembrane serine proteases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namestructural maintenance of chromosomes 4
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Synonyms gene
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Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-22
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Entrez gene record
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Pubmed identfication
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Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 646
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Synonyms gene
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Synonyms
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Locus
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Discovery year2006-05-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA MIR15/16 family
Gene info
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Identity
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Gene
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Long gene nameMYB proto-oncogene, transcription factor
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Synonyms gene name
- v-myb avian myeloblastosis viral oncogene homolog
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Synonyms
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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Classification
- Myb/SANT domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namephosphoenolpyruvate carboxykinase 1
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Synonyms gene name
- phosphoenolpyruvate carboxykinase 1 (soluble)
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Synonyms
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Locus
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Discovery year1990-09-10
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesurfactant protein C
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein C
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Synonyms
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Synonyms name
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Locus
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Discovery year1988-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BRICHOS domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namevariable charge X-linked 3B
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Synonyms
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Locus
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Discovery year2005-01-11
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Classification
- Variable charge X/Y family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMAF bZIP transcription factor
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Synonyms gene name
- v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
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Synonyms
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Locus
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Discovery year1991-08-01
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Entrez gene record
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Pubmed identfication
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Classification
- Basic leucine zipper proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameregulatory factor X1
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Synonyms gene name
- regulatory factor X, 1 (influences HLA class II expression)
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Synonyms
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Synonyms name
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Locus
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Discovery year1991-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Regulatory factor X family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameearly growth response 4
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Synonyms
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Locus
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Discovery year1992-07-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2H2-type
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VEGA ID
