Dihydroceramide, Autophagy inducer

• Catalog number
  SIH-398-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  13031-64-6
• Description
  Autophagy inducer
• Molecular weight
  343,54 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  C2 Dihydroceramide, D-erythro-N-Acetylsphinganine
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C20H41NO3
• Origin
  Synthetic
• Purity pourcentage
  ≥98%
• Soluble in
  Soluble in ethanol (5 mg/ml) or DMSO (5 mg/ml: dissolve in hot DMSO, then cool to RT).
• Physical appearance
  White solid.
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  6610273
• Scientific context
  Both in yeast and mammalian systems, dihydroceramide is the reaction intermediate found immediately prior to the final reaction product in the de novo synthesis of ceramide lipids. Recent studies have revealed that an accumulation of dihydroceramide will induce autophagy. Accumulation of dihydroceramide occurs due to inhibition of dihydroceramide desaturase, the enzyme responsible for the conversion of dihydroceramide into ceramide.
• Bibliography
  1. Gagliostro, V. et al. (2012). Int J Biochem Cell Biol, 44(12):2135-43. 2. Jiang, Q. et al. (2012). Int J Cancer, 130(3):685-93. 3. Signorelli, P. et al. (2009). Cancer Lett, 282(2):238-43.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Dihydroceramide (SIH-398), a Autophagy inducer. CAS #: 13031-64-6. Molecular Formula: C20H41NO3 . Molecular Weight: 343.54 g/mol. Chemical structure of Dihydroceramide, a Autophagy inducer (SIH-398). CAS # 13031-64-6. Molecular Formula: C20H41NO3 .
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products

• Gene target
  Dihydroceramide   Autophagy   inducer  
• Short name
  Dihydroceramide, Autophagy inducer
• Alternative name
  Dihydroceramide, Autophagy inducer

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