Doxorubicin Hydrochloride, Autophagy inducer

• Catalog number
  SIH-390-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  25316-40-9
• Description
  Autophagy inducer
• Molecular weight
  580 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  Adriamycin
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C27H29NO11•HCl
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  Soluble in water (50 mM).
• Physical appearance
  Red solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H350- May cause cancer. Precautionary statements: P201- Obtain special instructions before use. P308 + P313- IF exposed or concerned: Get medical advice/ attention.
• PubChem number
  443939
• Scientific context
  Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
• Bibliography
  1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55. 2. Chen, N. T. et al. (2012). PLoS One. 7(9). 3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66. 4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9. 5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4. 6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol. Chemical structure of Doxorubicin Hydrochloride, a Autophagy inducer (SIH-390). CAS # 25316-40-9. Molecular Formula: C27H29NO11 . HCl.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products

• Gene target
  Doxorubicin   Hydrochloride   Autophagy   inducer  
• Short name
  Doxorubicin Hydrochloride, Autophagy inducer
• Alternative name
  Doxorubicin Hydrochloride, Autophagy inducer

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