Chebulic acid

• Description :

  Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection[1][2][3][4][5].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Keap1-Nrf2; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/chebulic-acid.html

• Purity :

  99.89

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](CC(O)=O)[C@H]([C@H](O1)C(O)=O)C2=C(C(O)=C(C=C2C1=O)O)O)O

• Molecular Formula :

  C14H12O11

• Molecular Weight :

  356.24

• Precautions :

  H315, H319

• References & Citations :

  [1]Lee KW, et al. Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter. BMC Complement Altern Med. 2017 Jul 19;17 (1) :373.|[2]Silawat N, et al. Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats. Pharm Biol. 2013 Jan;51 (1) :23-9.|[3]Lee H S, et al. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction[J]. Journal of Ethnopharmacology, 2010, 131 (3) : 567-574.|[4]Lee H S, et al. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes[J]. Archives of Toxicology, 2007, 81: 211-218.|[5]Feng X H, et al. In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit[J]. Phytomedicine, 2021, 83: 153479.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [23725-05-5]