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Chebulic acid

CAT: 0804-HY-N4170-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4170-01Size:1 mg
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Description
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection[1][2][3][4][5].
CAS Number
23725-05-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/chebulic-acid.html
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@@H](CC(O)=O)[C@H]([C@H](O1)C(O)=O)C2=C(C(O)=C(C=C2C1=O)O)O)O
Molecular Formula
C14H12O11
Molecular Weight
356.24
Precautions
H315, H319
References & Citations
[1]Lee KW, et al. Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter. BMC Complement Altern Med. 2017 Jul 19;17 (1) :373.|[2]Silawat N, et al. Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats. Pharm Biol. 2013 Jan;51 (1) :23-9.|[3]Lee H S, et al. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction[J]. Journal of Ethnopharmacology, 2010, 131 (3) : 567-574.|[4]Lee H S, et al. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes[J]. Archives of Toxicology, 2007, 81: 211-218.|[5]Feng X H, et al. In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit[J]. Phytomedicine, 2021, 83: 153479.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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