Chebulinic acid (Standard)

• Description :

  Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

• CAS Number :

  [18942-26-2]

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Proton Pump; Reference Standards; TGF-beta/Smad

• Type :

  Reference Standards

• Related Pathways :

  Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others; Stem Cell/Wnt; TGF-beta/Smad

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/chebulinic-acid-standard.html

• Smiles :

  OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O

• Molecular Formula :

  C41H32O27

• Molecular Weight :

  956.68

• References & Citations :

  [1]Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47.|[2]Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20|[3]Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20 (6) :506-11.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards