Benzolamide

CAT: 0804-HY-118467-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118467-01Size:5 mg
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Description
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].
CAS Number
[3368-13-6]
Product Name Alternative
CL11366
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/benzolamide.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=NN=C(S1)NS(=O)(C2=CC=CC=C2)=O)(N)=O
Molecular Formula
C8H8N4O4S3
Molecular Weight
320.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1545-1554.|[2]Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25 (5) :1036.|[3]Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II

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