Benzamide

CAT: 0804-HY-Z0283-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-Z0283-01Size:100 mg
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Description
Benzamide (Benzenecarboxamide) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH) -induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].
CAS Number
[55-21-0]
Product Name Alternative
Benzenecarboxamide; Phenylamide
UNSPSC
12352005
Hazard Statement
H302, H341
Target
Endogenous Metabolite; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/benzamide.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(C1=CC=CC=C1)=O
Molecular Formula
C7H7NO
Molecular Weight
121.14
Precautions
H302, H341
References & Citations
[1]Cosi C, et al. Benzamide, an inhibitor of poly (ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996 Oct 7;735 (2) :343-8.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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