Benzamide-d5

CAT: 0804-HY-W711852-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W711852-01Size:5 mg
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Description
Benzamide-d5 (Benzenecarboxamide-d5) is deuterium labeled Benzamide. Benzamide (Benzenecarboxamide) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH) -induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].
CAS Number
[1235489-47-0]
Product Name Alternative
Benzenecarboxamide-d5; Phenylamide-d5
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Smiles
O=C(N)C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H]
Molecular Formula
C7H2D5NO
Molecular Weight
126.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cosi C, et al. Benzamide, an inhibitor of poly (ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996 Oct 7;735 (2) :343-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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