Products for Research Use Only
RegisterLogin

Regorafenib (Hydrochloride)

CAT: 0804-HY-13308-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13308-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[1].
CAS Number
835621-07-3
Product Name Alternative
BAY 73-4506 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; PDGFR; Raf; RET; VEGFR
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Regorafenib-Hydrochloride.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : ≥ 5.6 mg/mL|H2O : < 0.1 mg/mL
Smiles
ClC1=C(C(F)(F)F)C=C(NC(NC2=C(F)C=C(OC3=CC=NC(C(NC)=O)=C3)C=C2)=O)C=C1.Cl
Molecular Formula
C21H16Cl2F4N4O3
Molecular Weight
519.28
Precautions
H302
References & Citations
[1]Wilhelm SM, et al. Regorafenib (BAY 73-4506) : a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129 (1), 245-255.|[2]Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2 (1), 39-49.|[3]Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228 (2), 292-297.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
B-Raf; C-Raf; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

Chemical Information

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride
CAS Number835621-07-3
PubChem CID66577009
IUPAC Name4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrochloride
Molecular FormulaC21H16Cl2F4N4O3
Molecular Weight519.3
Topological Polar Surface Area92.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity686
SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.Cl
InChI
InChI=1S/C21H15ClF4N4O3.ClH/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,30,32);1H
InChIKey
ACSWJKPZXNIVMY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride
CAS: 835621-07-3
CID: 66577009
Formula: C21H16Cl2F4N4O3
MW: 519.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight519.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass518.0535584
Monoisotopic Mass518.0535584
Topological Polar Surface Area92.4 Ų
Heavy Atom Count34
Formal Charge0
Complexity686
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-10331-01Regorafenib
HY-10331BRegorafenib (mesylate)
HY-10331R-01Regorafenib (Standard)
HY-10331A-01Regorafenib (monohydrate)
HY-10331S-01Regorafenib-d3
HY-I0669-01Regorafenib impurity 1
HY-10331AR-01Regorafenib (monohydrate) (Standard)
HY-I0677-01Regorafenib impurity 8
HY-10331S1-01Regorafenib-13C, d3
HY-120422S-01N-Desmethyl Regorafenib-d3

Alternative Products

CatalogName
MBS3606094-01Regorafenib hydrochloride
A11546-50Regorafenib Hydrochloride 50mg
A11546-100Regorafenib Hydrochloride 100mg
A11546-10Regorafenib Hydrochloride 10mg
A11546-500Regorafenib Hydrochloride 500mg
A11546-25Regorafenib Hydrochloride 25mg
A11546-5Regorafenib Hydrochloride 5mg
A11546-10mM-DRegorafenib Hydrochloride 10mM * 1mL in DMSO
202436Regorafenib

Popular Products