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RFRP-1 (human)

CAT: 0804-HY-P1428-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1428-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RFRP-1 (human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1 (human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1 (human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively[1][2][3].
CAS Number
311309-25-8
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/rfrp-1-human.html
Purity
99.67
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](NC([C@H](CO)NC([C@H](CC3=CN=CN3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C67H101N19O14S
Molecular Weight
1428.70
References & Citations
[1]Takayoshi Ubuka, et al. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One. 2009 Dec 22;4 (12) :e8400.|[2]R Nichols, et al. Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides. 2010 Nov;31 (11) :2067-74.|[3]C Gouardères, et al. Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding. Neuropharmacology. 2007 Feb;52 (2) :376-86.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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