KER047

• Description :

  KER047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. KER047 can be used for the research of metabolic disease, such as fibrodysplasia ossificans progressiva (FOP) .

• Product Name Alternative :

  ALK2-IN-4

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/ker047.html

• Purity :

  99.35

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  FC(C=C1C(C(C2=C3N(C=C(C=N3)N4CCC(CC4)N5CCN(CC5)C)N=C2)=CC=N1)=C6)=C6OC

• Molecular Formula :

  C26H30FN7O

• Molecular Weight :

  475.56

• References & Citations :

  [1]Ullrich T, et al. Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva. Bioorg Med Chem Lett. 2022 May 15;64:128667.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  ALK2

• CAS Number :

  [2248154-85-8]