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KER047

CAT: 0931-T39764-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T39764-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2248154-85-8
Target
TGF-beta/Smad, ALK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Stem Cells
Purity
>99.99%
Bioactivity
KER047 (ALK2-IN-4) is an ALK2 inhibitor with potential anticancer activity and can be used in the study of non-small cell lung cancer.
Smiles
COc1cc2c(ccnc2cc1F)-c1cnn2cc(cnc12)N1CCC(CC1)N1CCN(C)CC1
Molecular Formula
C26H30FN7O
Molecular Weight
475.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Ker-047

KER-047 is under investigation in clinical trial NCT05927012 (A Study to Evaluate the Safety and Preliminary Efficacy of a Response-guided Dose Titration of KER-047 in the Treatment of Functional IDA (Iron Deficiency Anemia).).

CAS Number2248154-85-8
PubChem CID142464264
IUPAC Name7-fluoro-6-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Molecular FormulaC26H30FN7O
Molecular Weight475.6
XLogP2.8
Topological Polar Surface Area62
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity701
SMILES
CN1CCN(CC1)C2CCN(CC2)C3=CN4C(=C(C=N4)C5=C6C=C(C(=CC6=NC=C5)F)OC)N=C3
InChI
InChI=1S/C26H30FN7O/c1-31-9-11-33(12-10-31)18-4-7-32(8-5-18)19-15-29-26-22(16-30-34(26)17-19)20-3-6-28-24-14-23(27)25(35-2)13-21(20)24/h3,6,13-18H,4-5,7-12H2,1-2H3
InChIKey
UYQADNMBNQEQQG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ker-047
CAS: 2248154-85-8
CID: 142464264
Formula: C26H30FN7O
MW: 475.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight475.6
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass475.24958677
Monoisotopic Mass475.24958677
Topological Polar Surface Area62 Ų
Heavy Atom Count35
Formal Charge0
Complexity701
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-136773-01KER047
HY-136773A-01KER047 (succinate)

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