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DOTAP (methylsulfate)

CAT: 0804-HY-W127378-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W127378-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].
CAS Number
144189-73-1
Product Name Alternative
1,2-Dioleoyl-3-trimethylammonium-propane (methylsulfate)
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H331, H336, H351, H361, H372
Target
Liposome
Type
Biochemical Assay Reagents
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dotap-methylsulfate.html
Purity
99.94
Solubility
DMSO : 5 mg/mL (ultrasonic) |Ethanol : 100 mg/mL
Smiles
S(OC)(=O)(=O)[O-].C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C
Molecular Formula
C43H83NO8S
Molecular Weight
774.19
Precautions
H302, H315, H319, H331, H336, H351, H361, H372
References & Citations
[1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes. Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001.|[2]Crook K, et al. Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther. 1998 Jan;5 (1) :137-43.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 2
Citation 01
Signal Transduct Target Ther. 2025 Mar 24;10 (1) :101.|Adv Healthc Mater. 2023 Jan;12 (6) :e2202412.|bioRxiv. 2025 Oct 1.|Exploration. 2024 Jun 26;5 (1) :20240002.|Microbiol Spectr. 2025 Nov 5;13 (12) :e0143825.|Nanoscale. 2023 Nov 16;15 (44) :17825-17838.|Nat Immunol. 2025 Oct;26 (10) :1660-1672.|Pharmaceutics. 2023 Apr 30;15 (5) :1379.|SSRN. 2024 Nov 12.|University of Washington. 2025.|Drug Dev Ind Pharm. 2024 Aug 7:1-16.

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