Products for Research Use Only
RegisterLogin

FITM

CAT: 0804-HY-101845-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101845-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
CAS Number
932737-65-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FITM.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C)C1=NC(C2=NC=NC(NC(C)C)=C2)=CS1)C3=CC=C(F)C=C3
Molecular Formula
C18H18FN5OS
Molecular Weight
371.43
References & Citations
[1]Wu H, et al. Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014 Apr 4;344 (6179) :58-64.|[2]Bai Q, et al. Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis. Sci Rep. 2016 Feb 18;6:21763.|[3]Yamasaki T, et al. In vivo measurement of the affinity and density of metabotropic glutamate receptor subtype 1 in rat brain using 18F-FITM in small-animal PET. J Nucl Med. 2012 Oct;53 (10) :1601-7.|[4]Xie L, et al. Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe (18) F-FITM. Int J Cancer. 2014 Oct 15;135 (8) :1852-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1

Related Products

CatalogName
HY-66019-01FITC
HY-D2843FITC-PEG-FITC (MW 1000)
HY-DY1007-01FITC (solution)
HY-DN7075FFITC-inulin
HY-164816FITC-SAHA
HY-NP035Ovalbumin-FITC
HY-D2359Glucosamine-FITC
HY-D2841FITC-Heparin
HY-D2817FITC-PLL
HY-D3033FITC-Alginate

Alternative Products

CatalogName
BA5568-100FITM
A20047-10FITM 10mg
A20047-2FITM 2mg
A20047-25FITM 25mg
A20047-50FITM 50mg
A20047-100FITM 100mg
A20047-5FITM 5mg
A20047-1FITM 1mg
GTR17963604Fitm-2 Antibody
A20047-10mM-DFITM 10mM * 1mL in DMSO

Popular Products