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Metaxalone

CAT: 0804-HY-B0678-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-B0678-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia[1][2].
CAS Number
1665-48-1
Product Name Alternative
AHR438; NSC170959
UNSPSC
12352005
Hazard Statement
H302
Target
NF-κB; PGC-1α
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Metaxalone.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1OC(COC2=CC(C)=CC(C)=C2)CN1
Molecular Formula
C12H15NO3
Molecular Weight
221.26
Precautions
H302
References & Citations
[1]Pallio G, D'Ascola A, Cardia L, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22 (16) :8425. |[2]Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8 (3) :234-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Metaxalone

Metaxalone is an aromatic ether.

CAS Number1665-48-1
PubChem CID15459
IUPAC Name5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
Molecular FormulaC12H15NO3
Molecular Weight221.25
XLogP2.2
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity247
SMILES
CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C
InChI
InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
InChIKey
IMWZZHHPURKASS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metaxalone
CAS: 1665-48-1
CID: 15459
Formula: C12H15NO3
MW: 221.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight221.25
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass221.10519334
Monoisotopic Mass221.10519334
Topological Polar Surface Area47.6 Ų
Heavy Atom Count16
Formal Charge0
Complexity247
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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