NA-17

• Description :

  NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; MDM-2/p53

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Smiles :

  O=C1C2=CC=CC3=C2C(C(N1CCC4=CC=C5OCOC5=C4)=O)=CC=C3NCCCN(C)C

• Molecular Formula :

  C26H27N3O4

• Molecular Weight :

  445.51

• References & Citations :

  [1]Guohai Zhang, et al. A Novel Naphthalimide Compound restores p53 function in Non–Small–Cell by Reorganizing the Bak–Bcl-xl Complex and Triggering Transcriptiona regulation. JBC. December 14, 2015.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1708948-28-0]