Cyclophosphamide-d8 (hydrate)

• Description :

  Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

• Product Name Alternative :

  Cyclophosphamide-d8 (monohydrate)

• UNSPSC :

  12352005

• Target :

  DNA Alkylator/Crosslinker; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])Cl)P1(OCCCN1)=O.[H]O[H]

• Molecular Formula :

  C7H9D8Cl2N2O3P

• Molecular Weight :

  287.15

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12 (3) :167-72.|[3]Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60 (6) :1268-1279.|[4]al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96 (1) :1-6.|[5]Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33 (1) :53-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported