MS31

• Description:

  MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP) . MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM) . MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ms31.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCC1=CC (CN) =C (OC) C (OCCCN2CC (C=CC=C3) =C3C2) =C1

• Molecular Formula:

  C20H27N3O2

• Molecular Weight:

  341.45

• References & Citations:

  [1]Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1) . J Med Chem. 2019 Jul 24.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2366264-12-0