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MS31

CAT: 0804-HY-125837Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125837Size:1 Each
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Description
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP) . MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM) . MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells[1].
CAS Number
2366264-12-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms31.html
Solubility
10 mM in DMSO
Smiles
NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1
Molecular Formula
C20H27N3O2
Molecular Weight
341.45
References & Citations
[1]Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1) . J Med Chem. 2019 Jul 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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