MS39

CAT: 0804-HY-157581-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-157581-01Size:1 mg
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Description
MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N- (3-Chloro-4-fluorophenyl) -7-methoxy-6- (3- (piperazin-1-yl) propoxy) quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S, R, S) -AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC-CO-C9-acid (HY-139345) . MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1].
CAS Number
[2675490-92-1]
UNSPSC
12352005
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms39.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC(C(OCCCN1CCN(CC1)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O)=C5)=CC6=C5C(NC7=CC(Cl)=C(C=C7)F)=NC=N6
Molecular Formula
C55H71ClFN9O7S
Molecular Weight
1056.72
References & Citations
[1]Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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