Products for Research Use Only
RegisterLogin

ML148

CAT: 0804-HY-123548-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-123548-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].
CAS Number
451496-96-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
15-PGDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ml148.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(N1CCCCC1)C2=CC=C3N(C=NC3=C2)C4=CC=CC(C)=C4
Molecular Formula
C20H21N3O
Molecular Weight
319.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5 (11) :e13719.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

[1-(3-Methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone

[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone is a member of benzimidazoles.

CAS Number451496-96-1
PubChem CID3243760
IUPAC Name[1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone
Molecular FormulaC20H21N3O
Molecular Weight319.4
XLogP3.8
Topological Polar Surface Area38.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity448
SMILES
CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4
InChI
InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
InChIKey
YQNOQZALLOQMPY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of [1-(3-Methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
CAS: 451496-96-1
CID: 3243760
Formula: C20H21N3O
MW: 319.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight319.4
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass319.168462302
Monoisotopic Mass319.168462302
Topological Polar Surface Area38.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-121800ML138
HY-117861-01ML198
HY-136259-01ML188
HY-12755-01ML141
HY-W614623-01(S) -ML188

Alternative Products

CatalogName
456368-01ML148

Popular Products