Avobenzone (Standard)

Avobenzone (Standard)

• CAS Number: 70356-09-1
• UNSPSC Description: Avobenzone (Standard) is the analytical standard of Avobenzone. This product is intended for research and analytical applications. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2].
• Target Antigen: Apoptosis; Estrogen Receptor/ERR
• Type: Reference Standards
• Related Pathways: Apoptosis;Vitamin D Related/Nuclear Receptor
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/avobenzone-standard.html
• Smiles: O=C(C1=CC=C(C(C)(C)C)C=C1)CC(C2=CC=C(OC)C=C2)=O
• Molecular Weight: 310.39
• References & Citations: [1]Kojić M, et al. A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations. Phys Chem Chem Phys. 2016;18(32):22168-22178.|[2]Ahn S, An S, et al. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93(7):1903-1915.|[3]Yang C, et al. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50-57.|[4]Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83(2):264-272.
• Shipping Conditions: Room temperature