Avobenzone

• Description:

  Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/Avobenzone.html

• Purity:

  98.26

• Solubility:

  DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(C(C)(C)C)C=C1)CC(C2=CC=C(OC)C=C2)=O

• Molecular Formula:

  C20H22O3

• Molecular Weight:

  310.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kojić M, et al. A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations. Phys Chem Chem Phys. 2016;18 (32) :22168-22178.|[2]Ahn S, An S, et al. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93 (7) :1903-1915.|[3]Yang C, et al. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50-57.|[4]Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83 (2) :264-272.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [70356-09-1]