1-Methyladenosine-d3 (hydrochloride)

1-Methyladenosine-d3 (hydrochloride)

• UNSPSC Description: 1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis[1][2][3][4].
• Target Antigen: Endogenous Metabolite; Hedgehog; Isotope-Labeled Compounds; PPAR
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Purity: 98.05
• Solubility: DMSO : 50 mg/mL (ultrasonic;warming)
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN(C([2H])([2H])[2H])C3=N)O[C@@H]1CO.Cl
• Molecular Weight: 320.75
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Hauenschild R, et al. The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Res. 2015 Nov 16;43(20):9950-64.|[3]Banys K, et al. Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer. In Vivo. 2021 Jul-Aug;35(4):2059-2072.|[4]Wang Y, et al. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism[J]. Nature communications, 2021, 12(1): 6314.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported