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Cyclorasin 9A5 (TFA)

CAT: 0804-HY-P10051A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10051A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM[1].
UNSPSC
12352209
Target
Raf; Ras
Type
Peptides
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclorasin-9a5-tfa.html
Purity
99.57
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])[C@H](O)C)[C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC1=O)CC2=CC(C=CC=C3)=C3C=C2)=O)CCCNC(N)=N)=O)CC(C=C4)=CC=C4F)=O)CCCC)=O)CCC(N)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O.[x]
Molecular Formula
C75H108FN25O13.xC2HF3O2
Molecular Weight
1586.82 (free base)
References & Citations
[1]Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60 (12) :6567-6572.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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