PDK1-IN-2

PDK1-IN-2

• Product Name Alternative: MKS 492
• CAS Number: 1643958-85-3
• UNSPSC Description: PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer[1].
• Target Antigen: PDK-1
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdk1-in-2.html
• Purity: 98.90
• Solubility: DMSO : 4 mg/mL (ultrasonic;warming)
• Smiles: O=S(NC1=NC2=C(S1)C=C(Cl)C=C2)(C3=CSC4=C3C=CC=C4)=O
• Molecular Weight: 380.89
• References & Citations: [1]Rettenmaier T J, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1[J]. Proceedings of the National Academy of Sciences, 2014, 111(52): 18590-18595.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported