PDK1-IN-RS2

PDK1-IN-RS2

• CAS Number: 1643958-89-7
• UNSPSC Description: PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].
• Target Antigen: PDK-1
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdk1-in-rs2.html
• Purity: 98.50
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O
• Molecular Weight: 380.89
• References & Citations: [1]Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported