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S 1360

CAT: 0804-HY-12108Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12108Size:1 Each
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Description
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase (IC50: 20 nM) . The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1].
CAS Number
280571-30-4
UNSPSC
12352005
Target
HIV; HIV Integrase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/s-1360.html
Smiles
O=C(C1=CC=C(CC2=CC=C(C=C2)F)O1)/C=C(C3=NN=CN3)\O
Molecular Formula
C16H12FN3O3
Molecular Weight
313.28
References & Citations
[1]Neamati N. Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga[J]. Expert Opinion on Therapeutic Patents, 2002, 12 (5) : 709-724.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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