Chlorprothixene

Chlorprothixene

• CAS Number: 113-59-7
• UNSPSC Description: Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].
• Target Antigen: Bacterial; Dopamine Receptor; Histamine Receptor
• Type: Reference compound
• Related Pathways: Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/chlorprothixene.html
• Purity: 99.61
• Solubility: DMSO : 12.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2
• Molecular Weight: 315.86
• References & Citations: [1]Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42.|[2]B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched