Chlorprothixene

• Description:

  Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Bacterial; Dopamine Receptor; Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/chlorprothixene.html

• Concentration:

  10mM

• Purity:

  99.87

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles:

  CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2

• Molecular Formula:

  C18H18ClNS

• Molecular Weight:

  315.86

• Precautions:

  H301

• References & Citations:

  [1]Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19 (2) :538-42.|[2]B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268 (3) :1403-10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; H1 Receptor

• CAS Number:

  113-59-7