Chlorprothixene

CAT: 0804-HY-B0274-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0274-01Size:50 mg
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Description
Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].
CAS Number
[113-59-7]
UNSPSC
12352005
Hazard Statement
H301
Target
Bacterial; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chlorprothixene.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL
Smiles
CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2
Molecular Formula
C18H18ClNS
Molecular Weight
315.86
Precautions
H301
References & Citations
[1]Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19 (2) :538-42.|[2]B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268 (3) :1403-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; H1 Receptor

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