UH-AH 37

CAT: 0804-HY-120682Size: 1 EachDry Ice: NoHazardous: No

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Description

UH-AH 37 is a muscarinic (mAChR) antagonist. UH-AH 37 exhibits a higher potency in inhibiting muscarinic responses in intestinal tissue than cardiac tissue[1].

CAS Number

120382-14-1

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/uh-ah-37.html

Smiles

O=C1NC2=C(N(C3=C1C=CC=C3)C(CC4CCN(CC4)C)=O)C(Cl)=CC=C2.Cl

Molecular Formula

C21H23Cl2N3O2

Molecular Weight

420.33

References & Citations

[1]H N Doods, et al. UH-AH 37, an ileal-selective muscarinic antagonist that does not discriminate between M2 and M3 binding sites. Eur J Pharmacol. 1989 Feb 28;161 (2-3) :215-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

UH-AH 37

an ileal-selective muscarinic antagonist; RN from Toxlit

CAS Number	120382-14-1
PubChem CID	129139
IUPAC Name	1-chloro-11-[2-(1-methylpiperidin-4-yl)acetyl]-5H-benzo[b][1,4]benzodiazepin-6-one;hydrochloride
Molecular Formula	C21H23Cl2N3O2
Molecular Weight	420.3
Topological Polar Surface Area	52.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	28
Formal Charge	0
Complexity	564

SMILES

CN1CCC(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2C(=CC=C4)Cl.Cl

InChI

InChI=1S/C21H22ClN3O2.ClH/c1-24-11-9-14(10-12-24)13-19(26)25-18-8-3-2-5-15(18)21(27)23-17-7-4-6-16(22)20(17)25;/h2-8,14H,9-13H2,1H3,(H,23,27);1H

InChIKey

PMTAKOZVGKPLGD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 120382-14-1

CID: 129139

Formula: C21H23Cl2N3O2

MW: 420.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	420.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	419.1167324
Monoisotopic Mass	419.1167324
Topological Polar Surface Area	52.7 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	564
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-111006	(+) -UH 232
HY-W714110	UH 301 (hydrochloride)
HY-158380	UH-NIP-16
HY-129661-01	AH 7959
HY-121048	AH 7725
HY-W714505-01	AH 7563
HY-116500A	AH-1058
HY-W714509-01	AH 8507
HY-W325509-01	AH 8532
HY-101345-01	AH 11110A

Alternative Products

Catalog	Name
T29047-01	UH-AH 37
MBS5810791	UH 232
MBS5813618	UH 301
GTR19200712-01	(+) -UH 232
GTR19277353-01	(+) -UH 232 Maleate
GTR19262487-01	UH-NIP-16
B6446-10	(+)-UH 232 maleate
463527-01	R (+) -UH-301
465090-01	S (-) -UH-301 Hydrochloride
sc-253358	R (+) -UH-301 hydrochloride

UH-AH 37

Chemical Information

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