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Sulfatinib (Standard)

CAT: 0804-HY-12297R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12297R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulfatinib (Standard) is the analytical standard of Sulfatinib. This product is intended for research and analytical applications. Sulfatinib (Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM.
CAS Number
1308672-74-3
Product Name Alternative
Surufatinib (Standard) ; HMPL-012 (Standard)
UNSPSC
12352005
Target
FGFR; Reference Standards; VEGFR
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfatinib-standard.html
Smiles
O=S(CC1=CC=CC(NC2=NC=CC(OC3=CC4=C(NC(C)=C4)C=C3)=N2)=C1)(NCCN(C)C)=O
Molecular Formula
C24H28N6O3S
Molecular Weight
480.58
References & Citations
[1]PCT Int. Appl. (2011), WO 2011060746 A1 20110526.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Surufatinib

Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors).

CAS Number1308672-74-3
PubChem CID52920501
IUPAC NameN-[2-(dimethylamino)ethyl]-1-[3-[[4-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
Molecular FormulaC24H28N6O3S
Molecular Weight480.6
XLogP3.4
Topological Polar Surface Area121
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Heavy Atom Count34
Formal Charge0
Complexity733
SMILES
CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C
InChI
InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
InChIKey
TTZSNFLLYPYKIL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Surufatinib
CAS: 1308672-74-3
CID: 52920501
Formula: C24H28N6O3S
MW: 480.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight480.6
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Exact Mass480.19435995
Monoisotopic Mass480.19435995
Topological Polar Surface Area121 Ų
Heavy Atom Count34
Formal Charge0
Complexity733
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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