PP 3

• Description:

  PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pp-3.html

• Purity:

  98.78

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  NC1=C2C(N(C3=CC=CC=C3)N=C2)=NC=N1

• Molecular Formula:

  C11H9N5

• Molecular Weight:

  211.23

• Precautions:

  H315, H319

• References & Citations:

  [1]Traxler P, et al. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4- (phenylamino) pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40 (22) :3601-16.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [5334-30-5]