PP 3

• Description :

  PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pp-3.html

• Purity :

  98.78

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  NC1=C2C(N(C3=CC=CC=C3)N=C2)=NC=N1

• Molecular Formula :

  C11H9N5

• Molecular Weight :

  211.23

• Precautions :

  H315, H319

• References & Citations :

  [1]Traxler P, et al. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4- (phenylamino) pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40 (22) :3601-16.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5334-30-5]