Azide-PEG3-Tos

Azide-PEG3-Tos

• CAS Number: 178685-33-1
• UNSPSC Description: Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/azide-peg3-tos.html
• Solubility: 10 mM in DMSO
• Smiles: [N-]=[N+]=NCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
• Molecular Weight: 329.378
• References & Citations: [1]Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431.|[2]Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported