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Apigenin-d5

CAT: 0804-HY-N1201SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1201SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apigenin-d5 is a deuterated labeled Apigenin[1]. Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
CAS Number
263711-74-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; Cytochrome P450; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Purity
98.90
Smiles
OC1=C(C(O)=C2C(C([2H])=C(OC2=C1[2H])C3=CC([2H])=C(C([2H])=C3)O)=O)[2H]
Molecular Formula
C15H5D5O5
Molecular Weight
275.27
Precautions
H315, H319, H335
References & Citations
[1]Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37 (3) :629-34.|[2]Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11 (29) :4461-4.|[3]Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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