Apigenin

• Description :

  Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

• Product Name Alternative :

  4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Cytochrome P450; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Autophagy; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Apigenin.html

• Purity :

  99.58

• Solubility :

  DMSO : 80 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1

• Molecular Formula :

  C15H10O5

• Molecular Weight :

  270.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37 (3) :629-34.|[2]Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11 (29) :4461-4.|[3]Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 2

• Isoform :

  CYP2

• CAS Number :

  [520-36-5]