Apigenin

• UNSPSC Description:

  Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

• Target Antigen:

  Autophagy; Cytochrome P450; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Apigenin.html

• Purity:

  99.58

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL

• Smiles:

  OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1

• Molecular Weight:

  270.24

• References & Citations:

  [1]Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37(3):629-34.|[2]Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11(29):4461-4.|[3]Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 2

• CAS Number:

  520-36-5