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Rupintrivir-d7

CAT: 0804-HY-106161S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106161S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rupintrivir-d7 is a deuterated labeled Rupintrivir[1]. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect[2][3].
Product Name Alternative
AG7088-d7
UNSPSC
12352005
Target
Enterovirus; Isotope-Labeled Compounds; Virus Protease
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
CC1=CC(C(N[C@H](C(C[C@H](C(N[C@H](/C=C/C(OCC)=O)C[C@@H]2CCNC2=O)=O)CC3=CC=C(F)C=C3)=O)C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)=NO1
Molecular Formula
C31H32D7FN4O7
Molecular Weight
605.71
References & Citations
[1]Patick AK, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43 (10) :2444-50.|[2]Danov O, et al. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res. 2019 Oct 22;20 (1) :228.|[3]Dragovich PS, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem. 1999 Apr 8;42 (7) :1203-12.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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