ZM241385-d7

• UNSPSC Description:

  ZM241385-d7 is a deuterated form of ZM241385 (HY-19532). ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].

• Target Antigen:

  Adenosine Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C([2H])C([2H])=C(CCNC2=NC3=NC(C4=C([2H])C([2H])=C([2H])O4)=NN3C(N)=N2)C([2H])=C1[2H]

• Molecular Weight:

  344.38

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wang Z, et al. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drugcandidate ZM241385. PLoS One. 2010 Nov 8;5(11):e13883. |[3] Linden J, et al. Characterization of human A(2B) adenosine receptors: radioligandbinding, western blotting, and coupling to G(q) in human embryonickidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported